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This GHR upregulation sensitises local cells to circulating GH, potentiating GH-induced JAK2/STAT signalling and stimulating collagen matrix synthesis, IGF-1 production, and fibroblast proliferation providing a mechanism through which BPC-157 engages the GH/IGF-1 axis at the tissue level without altering systemic GH secretion

These systems also enhance patient adherence by overcoming barriers associated with injections or oral medications

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Primary sources of carnitines are through dietary intake, de novo biosynthesis, and renal tubular reabsorption (Reuter & Evans 2012)