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Subsequently, ATF4 binds to the amino acid response element (AARE) of gene promoter to further promote the transcription of genes involved in amino acid metabolism and stress response, such as SLC7A11, so that cells can cope with amino acid constraints (Stockwell and Jiang, 2020)
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Clinical examination showed a height of 84.5 cm (below third percentile), weight of 11.2 kg (below third percentile), and OFC of 50 cm (P50)
Xue Q, Kang R, Klionsky DJ, Tang D, Liu J, Chen X
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