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[17] [18] The company merged with Millendo Therapeutics in 2018

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The transition of macrophages from a pro-inflammatory phenotype to an alternative activated or anti-inflammatory phenotype plays a crucial role in the shift from the inflammatory phase to the proliferative phase of wound healing

doi: 10.3389/fcimb.2022.861703 101 NaendrupJHGarcia BorregaJEichenauerDAShimabukuro-VornhagenAKochanekMBllB

While full restoration to youthful levels isnt guaranteed and NAD+ therapy research in humans is still a bit limited, there are studies that support its superiority over diet and exercise alone in significantly raising NAD+ concentrations and promoting healthier aging, especially after 40 when natural production declines sharply