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Regardless, the aforementioned research by Ng et al
mutant G710E loses the carnitine palmitoyl-transferase activity, however, maintains its succinylation activity, suggesting that Gly710 is very important for CPT1A succinyl-transferase activity (Kurmi et al., 2018)
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2.2.3 Lysosomal oxidative stress and TAO Lysosomes play critical roles in cellular degradation, regulation, and immunity ( Inflammatory response: Lysosomal oxidative stress triggers inflammatory reactions, involving infiltration and activation of immune cells, exacerbating tissue inflammation and damage in TAO ( Apoptosis: Oxidative stress from lysosomal enzymes can induce cell apoptosis, further complicating TAO pathology by promoting tissue damage ( Immune regulation imbalance: Lysosomal oxidative stress disrupts antigen degradation and presentation, potentially exacerbating autoimmune responses in TAO ( Impact on other organelles: Lysosomal oxidative stress can interact with other organelles, such as the ER and mitochondria, affecting cellular signaling and function ( Further research is necessary to elucidate the role of lysosomal oxidative stress in thyroid-related eye conditions, confirming and expanding upon existing theoretical frameworks and research findings
