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Compared with lixisenatide, exenatide twice daily, liraglutide, albiglutide and dulaglutide, semaglutide is associated with highest nausea and vomiting rates, yet also with highest rates of improvement in glycemic control and weight loss (132)

Semaglutide and tirzepatide injections are administered weekly over several months, while phentermine is used for a shorter periodoften three to four monthsduring the early phase

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The clinical pharmacy team can provide in-service education about such situations and guide the healthcare team in conducting proper medication histories and making necessary adjustments

There is some evidence suggesting that certain SSRIs such as fluoxetine and sertraline may improve insulin sensitivity in some patients, though this effect is inconsistent and should not be relied upon for diabetes management