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Note: Ozempic has received FDA approval only for treating type 2 diabetes

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Effects of BTR signaling on gut hormone secretion An increasing number of studies in both preclinical and clinical models have evaluated the effects of BTR agonists on ghrelin, CCK, GLP-1, and PYY secretion, although the specificity of bitter compounds for different T2Rs is poorly defined and the function of intestinal BTR sensing in either obesity or type 2 diabetes has not been thoroughly investigated

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2007, 94.Tupe RP, Chiplonkar SA