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Materials and methods Literature search A search algorithm was entered in the MEDLINE/Pubmed database up to March 2024 using the following terms in all fields: [(proBDNF OR pro-BDNF OR mBDNF OR mature BDNF) AND (enzyme-linked immunosorbent assay OR ELISA) AND Serum]

Preexisting health conditions Conditions like diabetes, gastrointestinal issues, or B12 deficiency may require dosage modifications for safety and effectiveness

[Google Scholar] 37.Kattoor A.J., Goel A., Mehta J.L

Tirzepatide, conversely, is a dual GLP-1/GIPR receptor agonistit binds both pathways simultaneously

There is also a potentially protective neuropeptide, apelin-13, which has been shown to play an important role in neurological impairments such as depression and anxiety [99]