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Semaglutide (Wegovy, Ozempic) received FDA approval for chronic weight management in 2021, followed by tirzepatide (Zepbound) in 2023, both demonstrating substantial weight loss in clinical trials

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Knowing how long it remains in your system can help you anticipate when side effects might ease after stopping the medication

However, drugs in this class can increase the risk of heart failure in some people, and may also cause fluid retention in the legs and feet