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Theres no reliable way to predict in advance whether someone will be a positive responder or will experience worsening symptoms, which is another argument for extreme caution and close monitoring if trialling these drugs in someone with known MCAS

Besides weight reduction, patients often report higher energy levels, decreased joint pain, better sleep quality, heightened self-confidence, and lowered risks for heart disease and diabetes

Additionally, 20 mg/kg apigenin for 3 weeks in male mice treated with CUMS caused a decrease in the levels of provocative brain cytokines (IL-18 and IL-1), changes in oxidative stress parameters (reducing malondialdehyde (MDA) levels, and restoring the reduced glutathione (GSH) levels), and a decrease in expression of NLRP3 inflammatory activation (Li et al., 2016b)

Your doctor will likely recommend gradually reducing your dose over time

To the best of my knowledge, generic Semaglutide is synthetic, not a biologic