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Our central hypothesis is that CR activates metabolic reprograming pathways in DM defined by cancer hallmarks (e.g., uncontrolled cell proliferation, tumor suppressors loss etc.), while suppressing immune system surveillance

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The study also noted that B420 increased the abundance of Akkermansia muciniphila in participants' gut microbiota and increased fecal SCFA concentrations including butyric acid, which has been shown to stimulate GLP-1 secretion from intestinal L-cells

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10.1111/dom.12121 62 PozzilliP.NorwoodP.JdarE.DaviesM