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[117] also investigated the impaired immune response with age in relation to carotenoid intake (-carotene, lycopene, lutein), finding that age-related changes in immune markers such as higher serum IgA levels and altered lymphocyte subpopulations (increase in memory Th cells (CD4 + CD45RO+) and natural killer (NK) cells along with a decrease in nave Th cells (CD4 + CD45RA+) and B lymphocytes) and impaired neutrophil activity, which could be modulated by carotenoid intake, depended only marginally on dietary carotenoid depletion and repletion [117]