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While supplemental folic acid has the greatest homocysteine-lowering effect of the B-vitamins, co-supplementation of folic acid plus vitamin B 12 can lower homocysteine levels even further

FIGURE 3 3.2.2 Modulation of macrophage polarization by quercetin Quercetin has been shown to effectively modulate macrophage polarization by shifting the balance from the M1 to the M2 phenotype, thereby fostering an anti-inflammatory microenvironment

It does this by stimulating the release of certain cytokines known to be involved in the regulation of inflammatory responses

doi: 10.1210/jc.2013-2218 100 RashidGKhanNAElsoriDYounessRAHassanHSiwanDet al

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