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Peripheral neuropathy is associated with an increase of reactive oxygen species and a decrease in endogenous antioxidants

Additionally, key glycolytic enzymes such as aldolase, triosephosphate isomerase, GAPDH, phosphoglycerate mutase 1, and enolase become functionally impaired due to oxidative stress in AD, reducing glucose metabolism efficiency

s.c.), a significant reduction in the 5-HT synthesis rate was observed in the dorsal raphe nucleus, and significant increases were observed in the substantia nigra, lateral caudate, accumbens nucleus and superior olive