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Although ICH Q2(R2) is primarily intended for pharmaceutical analytical procedures, its fit-for-purpose validation principles may be used as a non-mandatory scientific reference for research-reagent testing

however, the mechanism is poorly understood [131, 132]

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The combination cagrilintide and semaglutide group had a time in range of 88.9% at 32 weeks compared with a 76.2% time in range with semaglutide and a 71.7% time in range with cagrilintide