When dietary changes or oral supplements just arent cutting itespecially for those with absorption issuesB12 injections often become the most effective way to get back on track
Rather than raising NAD+ systemically (as NMN or NR supplementation does), NNMT inhibition preserves NAD+ specifically in the tissue where metabolic dysfunction is most pronounced a precision approach that appeals to researchers studying tissue-specific metabolic regulation
Its now widely used in both dermatology and trichology for improving skin texture, reducing wrinkles, and, most importantly for our discussion, revitalising hair follicles
The 1 mg community standard is the conservative entry point documented in community protocols
One phase two trial (mean age 58, with no upper age limit) demonstrated mean reduction in body weight of 15.6% in participants taking CagriSema, compared to 5.1% and 8.1% with semaglutide and cagrilintide in monotherapy, respectively, over 32 weeks