Increasingly, the drugs are being offered in compounded alternatives, he adds, which also could offer lower-cost alternatives, but once again increase demand and utilization. How will Trump affect GLP-1s
Clinical data suggests 2040% of GLP-1 users experience digestive complaints ranging from mild bloating to moderate nausea, with indigestion occurring most commonly during dose escalation or in the first 48 weeks of treatment
"So you have a wide variety of people promoting these medications, anywhere from personal trainers all the way up to physicians," Varney said
Why real-world data matters for GLP-1 research Clinical trials, limited in scope and duration, cannot provide the longitudinal and representative data needed to fully capture the broad impacts of GLP-1s in real-world settings
Singh highlighted two 2025 studies: one found GLP-1 use was associated with a lower incidence of progression to advanced AMD, including neovascular AMD and geographic atrophy, while another reported an increased risk of neovascular AMD among GLP-1 users
