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If affordable, basal insulin analogue formulations are preferred to NPH insulin because of their reduced risk of hypoglycaemia, particularly nocturnal hypoglycaemia, when titrated to the same fasting glucose target [327]

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The distribution and concentration of oxygen functionalities create a heterogeneous electronic structure with insulating regions (oxygen-rich domains) interspersed with conductive graphitic regions (pristine sp 2 carbon domains) 49

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