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doi: 10.1016/j.tcm.2021.12.008

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A 2.5 mg dose of tirzepatide and a 0.25 mg dose of semaglutide are both "starting doses" that serve the same purpose, tolerance building, but the actual pharmacology behind each number is unique

Semaglutide is a GLP-1 medication approved by the US Food and Drug Administration (FDA) that controls blood sugar levels in people with type 2 diabetes, reduces the risk of heart attack and stroke in people with heart disease and type 2 diabetes or obesity, and promotes weight loss in people with overweight and obesity