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Reconstituted peptides follow a steeper curve: 4 hours at 20C causes approximately 8% loss, 12 hours causes 2530% loss, and 24 hours renders the solution effectively inactive for research purposes

Common GLP-1 side effects include: Nausea Vomiting Diarrhea or constipation Abdominal discomfort Fatigue Acid reflux/heartburn Dizziness (related to dehydration) To improve tolerability, healthcare providers typically start patients on a low dose and increase it gradually

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The VA-IMPACT (NCT02915198) is ongoing to evaluate the effect of metformin on the prevention of cardiovascular events in patients with impaired glucose tolerance and established cardiovascular disease, but at the moment, the strength of evidence of metformin as a drug to prevent ORCVD may be inferior to GLP-1RAs

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