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Since many GLP-1 users have type 2 diabetes or prediabetes, maintaining optimal magnesium levels supports the metabolic improvements these medications provide

Tirzepatide is a dual GLP-1 and GIP receptor agonist licensed for type 2 diabetes treatment in the UK Cold extremities may relate to weight loss, reduced subcutaneous fat, metabolic changes, or dehydration rather than direct drug effects Patients should seek medical assessment if cold extremities occur with colour changes, numbness, pain, or ulceration Common recognised side effects include gastrointestinal symptoms such as nausea, vomiting, diarrhoea, and constipation Regular monitoring during treatment is essential as per NICE guidance for GLP-1 receptor agonist therapy Table of Contents Does Mounjaro Cause Cold Hands and Feet

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