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AMPK activation (AICAR): a well-characterised AMP-activated protein kinase agonist used extensively in cellular energy-sensing research

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KPV additionally supports gut barrier epithelial integrity through epithelial cell-protective and tight junction-promoting activity, and provides antimicrobial activity against a range of pathogens relevant to gastrointestinal and skin health addressing the microbial dimension of gut dysbiosis and skin conditions that frequently co-occur with inflammatory gut barrier dysfunction

doi: 10.1016/j.pharmthera.2005.05.007