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SAMP8 mice showed age-related cognitive dysfunction with reduced learning ability score as well as elevated amyloid beta (A) concentration in the circulation (Kamei et al., 2017)

During sleep, reactivation of primed circuits leads to more permanent changes in synaptic weights via stabilization of structural plasticity

People who are heterozygous for CBS deficiency (between 1 in 70 to 1 in 200 in the general population) have normal homocysteine levels in 30% to 50% of cases

JZ is an employee of Merck KGaA, Darmstadt, Germany

Given that nephrotic non-inflammatory glomerulonephritis is a hallmark of many glomerular disorders, treatment approaches aimed at modifying podocyte activity are likely to be beneficial (8)