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In a 12-week study, participants receiving 1 mg daily lost an average of 2.6 kg (approximately 5.7 pounds) compared to 0.8 kg in the placebo group

54 The phase 3 randomised controlled Study of Retratrutide in Participants with Obesity and Cardiovascular Disease (TRIUMPH-3) seeks to determine the percentage change from baseline in body weight in patients with BMI 35 kg/m 2 and established CVD (clinical trial number NCT05882045

Under most conditions this may be the most important short-term regulatory signal, although it is, of course, possible that other regulatory effects play a role as well

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