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The dosage schedule when switching after high-dose tirzepatide accounts for this partial adaptation and can help minimize the transition diarrhea

Vancampfort D, Mugisha J, Hallgren M, De Hert M, Probst M, Monsieur D, et al

"We are losing around 20% of muscle mass, but that is not different from diets that restrict calorie intake

Recovery is brief, with redness and mild swelling for a few days, so it appeals to those seeking minimal disruption