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However, patients who lose 1015% of body weight on GLP-1 and then stop the medication often do not regain every pound lost

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Treatment of diet-induced obese mice with sitagliptin (4 g/kg), a DPP-4 inhibitor, significantly reduced the expression of inflammatory genes including monocyte chemotactic protein- (MCP-) 1, IL-6, IL-12(p40), IL-12(p35), and IFN- -induced protein 10 (IP-10) in pancreatic islets and improved glucose-stimulated insulin secretion in isolated islets [19]

PMID: 33513711

Endocrine System Regulation: Studied for its potential to modulate the secretion of ACTH and growth hormone under various stress conditions