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doi: 10.1038/ki.2014.115 105

Transcriptional regulation of preproglucagon (Gcg) Preproglucagon (Gcg) is expressed in pancreatic -cells, in enteroendocrine L-cells throughout the gut, predominantly in the distal ileum and colon, and in a population of neurons in the nucleus tractus solitarii (NTS) of the brainstem [52,[84], [85], [86], [87], [88], [89]]

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Conversely, guiding immune cells toward an anti-inflammatory phenotype, such as M2-skewed macrophages, can enhance lipid clearance and reduce iron overload in OA joints, potentially lowering ferroptosis incidence (109) ( Figure 2 )