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GHK-Cu promotes angiogenesis (new blood vessel formation), which raises theoretical concerns about supporting tumor growth, though the peptide also demonstrates documented anti-cancer gene expression effects

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In December 2024 , the FDA determined that AOD-9604 (both free base and acetate forms) should not be included on the 503A Bulks List for pharmaceutical compounding, citing concerns over limited long-term safety data, peptide impurities, and potential immunogenicity