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Helper or cytotoxic T cells secrete factors such as interferon- (IFN-) and IL-17 that compromise cartilage integrity (111, 112)

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Acetaminophen produces neurotoxic effects on rat brain neurons both in vitro and in vivo , its use during pregnancy is associated with teratogenic defects in testicular function and the gastrointestinal tract, and there is increased incidence of asthma in maternally exposed and postnatally exposed children

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