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Protein-sulfenic and glutathione sulfenic acids result from reaction with endogenously produced ROS or RNS but usually these species are rapidly transformed in prot-SSG (GSSR) or GSSG as more stable derivatives

The efficacy of the peptides was dependent on them being dimeric, i.e

The red curve (our Case 4, severe ALI) shows a rightward shift, lower peak, and narrowing, where the lungs safe operating window is shrinking as recruitability is lost

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