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Decades of public health and medical prevention and treatment efforts have successfully decreased the role of these traditional risk factors, yet coronary artery disease remains a major cause of death worldwide

doi: 10.3389/fnagi.2025.1737001 Received 31 October 2025 Revised 13 December 2025 Accepted 17 December 2025 Published 10 February 2026 Volume 17 - 2025 Edited by Slawomir Jakiela, Warsaw University of Life Sciences, Poland Reviewed by Sajad Fakhri, Kermanshah University of Medical Sciences, Iran Emre Adigzel, Karamanolu Mehmetbey University, Trkiye Updates Copyright 2026 Guo and Chi

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Among the most frequently reported adverse effects are minor and self-limiting such as local injection site erythema, transient hormonal shifts, and receptor desensitization with prolonged or high-frequency use