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doi: 10.1080/17425255.2018.1488965 18 BagyanszkiMKrecsmarikMDe WinterBYDe ManJGFeketeEPelckmansPAet al

A specialized transporter for the uptake of biotin and pantothenic acid was identified in cultured cells derived from the lining of the colon, suggesting that humans may be able to absorb pantothenic acid and biotin produced by intestinal bacteria (39)

The abrupt cessation of GLP-1R agonists in individuals with metabolic disorders may lead to adverse effects, as seen in a case where a patient developed IIH after discontinuing duraglutide [29]

Meanwhile, SCP2-1 reduced the expression level of NLRP3, M-caspases-1, and reduced the excessive deposition of -amyloid (A) associated with neuronal degeneration, thereby exerting a neuroprotective effect (118)

429,430,431,432,433 The mechanism of enhanced glycolysis involves the activation of pyruvate kinase isoenzyme M2 (PKM2), which triggers downstream inflammatory factors in a hypoxia-inducible factor 1 (HIF-1)-dependent manner