In preclinical models, NNMT inhibition has been shown to mimic and boost exercise-mediated improvements in muscle function, even in sedentary subjects
This reaction simultaneously depletes two critically important metabolic cofactors: SAM (the universal methyl donor for hundreds of epigenetic and biosynthetic reactions) and nicotinamide (the precursor for NAD+ biosynthesis via the salvage pathway)
Bypassing the digestive system is the only reliable route
Your provider may recommend laboratory testing to evaluate for anemia, thyroid dysfunction, electrolyte imbalances, vitamin deficiencies, kidney function, or liver function
While some patients are able to get enough B12 through their consumption of red meats, dairy products, and fish, other patients find their dietary restrictions or metabolism limit the amount of B12 they receive