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GLP-1-based therapies and resmetirom operate through distinct and potentially complementary mechanisms: while resmetirom exerts direct hepatic effects by activating THR- to enhance mitochondrial function, reduce hepatic lipogenesis, and promote lipid oxidation specifically in hepatocytes, GLP-1 RAs and multi-agonists address the upstream metabolic drivers of MASLD including insulin resistance, obesity, and systemic inflammation
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Camporeale G, Zempleni J
A notable clinical trial involving oral semaglutide ( Rybelsus ) showed substantial weight loss in participants over 68 weeks
A balanced diet and regular physical activity can significantly enhance their effectiveness, leading to more sustainable health outcomes
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