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Keep in mind, though, that best outcomes were reported from those who used B12/MIC in combination with regular exercise and a reduced-calorie meal plan

However, the rationale for their concurrent use is supported by their complementary mechanisms of action and the clinical benefits observed in treating coexisting conditions such as obesity and depression

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Experts say these side-effects can relate to the way the medications work: slowing the progress of food through the digestive tract, slowing stomach emptying and affecting signalling from the gut to the brain