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Pharmaceutical contaminants are increasingly recognized as a class of emerging pollutants due to their widespread occurrence in various environmental compartments and their potential for toxicological impacts on both humans and wildlife

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Vpr induces oxidative stress by stabilizing p53 protein, increasing transforming growth factor-beta protein levels and ROS production, and suppressing antioxidant enzymes 118,119,120

The formation of aggregates is variable and inconsistent and depends on the cell type used and on the experimental conditions of the GST pulldown assay