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Downstream transcription factors showed dramatic upregulation: c-Fos by 4.99-fold, c-Jun by 7.05-fold, and Egr-1 by 3.70-fold

doi: 10.1155/2013/782497 66 GuoTBondNDJouWGavrilovaOPortasJMcPherronAC

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Essa constatao levou hiptese de que a reduo natural do GHK poderia estar associada s alteraes observadas na capacidade de renovao dos tecidos durante o processo de envelhecimento, estimulando uma nova linha de pesquisas voltada ao papel desse peptdeo na biologia cutnea