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When it occurs, it is more often linked to rapid weight loss or changes in nutrition rather than a direct effect of the medication itself

Radiation damage leads to a significant reduction in the abundance of bile acid-metabolizing commensal taxa (e.g., Lactobacillus and Bifidobacterium ) in the gut, thereby blocking the secondary bile acid production pathway and causing bile acid metabolism disorders 150

Nakamura H, Tanaka T, Zheng C, Afione SA, Warner BM, Noguchi M, et al

Special care is needed for older adults taking GLP-1 receptor agonists

Put something like a towel between your skin and the ice or cold pack to minimize the risk of frostbite