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This mitochondrial connection is particularly relevant for lupus, where mitochondrial dysfunction in immune cells has been documented, and for fibromyalgia and chronic fatigue that frequently accompany autoimmune conditions

And if youre sensitive to caffeine, Thesis also has the option to remove the caffeine (and L-theanine), so its not a deal-breaker if you find that combining a nootropic with your morning cup of coffee is too much

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Yuksel, C., et al

It is important to note the regions of the brain that are more susceptible to the changes in BBB integrity as regions like the hippocampus and amygdala are heavily affected in neurodegenerative disease as they are vital for long-term memory and processing emotions and behavior