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1 Introduction Glucagon-like peptide-1 (GLP-1RA) receptor agonists possess multiple favorable metabolic, anti-inflammatory effects and their use is associated with marked body weight reduction ( Semaglutide is a potent GLP-1RA used in the treatment of T2DM with proven cardiovascular benefits ( Multiple mechanisms have been proposed to explain the cardiovascular benefit of semaglutide

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Compounded semaglutide comes in standard pharmaceutical vials, dramatically reducing packaging and device costs

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A phase-1 trial (NCT04513704) is being conducted on 156 healthy subjects to examine various pharmacokinetic parameters (steady state plasma concentration, C max , t max ) after daily-once oral semaglutide administration under different dosing schedules