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Together with the absence of symptoms associated with IGF-1-mediated effects such as fluid retention, tissue edema, or impaired glucose tolerance, these results demonstrate that AOD-9604 does not activate the growth hormone/IGF-1 pathway and therefore functions through an entirely appetite-independent mechanism

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Jakubowski and collaborators have recently reported that cells efficiently convert homocysteine into homocysteine thiolactone by methionyl-tRNA synthetase (Jakubowski et al, 2000b)

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Research remains limited, and the effects of BPC-157 on blood pressure have not been fully established in large human studies