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Months of lower body weight produce lasting benefits including improved insulin sensitivity, reduced hepatic fat, decreased inflammatory markers, and potentially improved cardiovascular remodeling

Reduced amyloid plaque load and chronic inflammation response (microglial activation)

Dalle Grave R

Results are presented as mean standard deviation

These include: Nausea the most frequently reported adverse effect, particularly during dose escalation Vomiting Diarrhoea Constipation Decreased appetite (which, whilst therapeutically intended, can occasionally be excessive) Abdominal discomfort or pain These effects are generally dose-dependent and tend to be most pronounced during the initial weeks of treatment or when the dose is increased