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When Nrf2 is activated, it triggers the transcription of genes that detoxify reactive oxygen species (ROS) and eliminate damaged cellular components

The RAAS is a complex physiological pathway that regulates BP, fluid and electrolyte balance, and systemic vascular resistance [88, 89]

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There are few other clear human data on serum GPX3 levels in type 1 diabetes, while there are several reports on type 2 diabetes with other comorbidities [21,22,23], including suggestions that the serum/plasma levels are related to oxidative stress and dependent on the extent of disease progression [24]

SHRSP-Tg(Gstm1)1WKY 0.024 0.002mmol/l and SHRSPTg(Gstm1)2WKY 0.021 0.002mmol/l