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First, we tested HCT116 cells cultured in DMEM media in which glucose (25 mM) was replaced with galactose (25 mM), a method previously described to promote enhanced TCA cycle flux (Fig

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CPEO displays notable genetic heterogeneity, being sporadic in around 50% of cases involving single large de novo mtDNA deletion [182], with inherited forms involving mutations in genes such as RRM2B, TWNK, OPA1, POLG , and ANT1 [183]

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Nevertheless, its usage solely for improving sleep is not recommended