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RNAseq was used to measure genome-wide mRNA levels to discover the gene-expression signature that best describes the overall medication effects

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doi: 10.1016/j.heares.2005.10.015

These oncogenes contribute to therapy resistance and progression to the aggressive castration-resistant PCa

Since adipose tissue is responsive to endotoxins, bacterial translocation may provide a mechanism whereby the gut microbiome can modulate the adipose metabolome (for review, Kruis et al., 2014 23 ) and consequently exacerbate obesity and its related comorbidities