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While preclinical studies and anecdotal evidence suggest potential benefits, the lack of comprehensive clinical trial data limits our understanding of its full therapeutic potential and possible side effects
Long-term metformin use may also be linked with low vitamin B12 in some people
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Conclusion and perspectives In summary, we begin with the key role of changes in synaptic plasticity in sustained antidepressant effect, focus on synaptic plasticity, and followed by a discussion of the modulation of synaptic plasticity by neurexins to demonstrate the potential and feasibility of studies of sustained antidepressant effect through the modulation of synaptic plasticity by neurexins
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