SGLT-2 inhibitors significantly reduced cardiovascular (RR = 0.88) and total (RR = 0.87) death, as compared with DPP-4 inhibitors, while GLP-1 RA reduced total death only (RR = 0.87)
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This effect helps with fullness, but it can also worsen nausea, bloating, or reflux in some people, especially after large evening meals
Noyan-Ashraf MH, Shikatani EA, Schuiki I, Mukovozov I, Wu J, Li RK, Volchuk A, Robinson LA, Billia F, Drucker DJ, et al: A glucagon-like Peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity
I started on my program 1 yr ago at 170 lbs with 16% pbf and the transformation is beyond what I expected at 180 lbs with 10% pbf