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Peripheral nerve damage involves ischemia, Schwann cell dysfunction and axonal degeneration, particularly affecting unmyelinated C fibres organized in Remak bundles, ultimately leading to demyelination in more severe cases

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325 GIPR is downregulated in adipose tissue during insulin-resistant states, such as obesity, and several studies suggest that GIP augments insulin actions in adipose tissue

All state Medicaid programs cover the drugs for Type 2 diabetes, but only 14 provide some form of coverage to treat obesity

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