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In the KEYNOTE-119 trial, monotherapeutic pembrolizumab did not significantly improve OS in patients with previously treated metastatic TNBC compared to chemotherapy, which might inform future research of pembrolizumab monotherapy for selected patients, specifically those with PD-L1-enriched tumors, and combinatorial approach might be necessary for the treatment of patients with metastatic TNBC

The IC 50 values were calculated with the Excel software

Nano-carriers provide an option as these are designed in such a manner that they can mimic the delivery of minerals required for the brain to traverse the drug molecule through the bloodbrain barrier

During iron metabolism, less than 10% of the iron demand is met by intestinal absorption, and the remaining iron is exported by ferroportin [4]