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Novel strategies for PI3K/AKT/mTOR pathways The activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway plays a crucial role in endocrine resistance, positioning this pathway as a potential therapeutic target

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doi: 10.1016/j.yrtph.2016.03.005 48 LangH.LiQ.YuH.LiP.LuZ.XiongS.et al

These are essential to validate biological activity in a more physiological context, evaluating complex cellular processes and possible toxicity, which brings the results closer to in vivo reality

Glucose-Lowering Drugs to Reduce Cardiovascular Risk in Type 2 Diabetes