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Similar effects were seen with liraglutide, the active ingredient in the weight loss drug Saxenda, and the diabetes drug Victoza

Brain Fog, Burnout, and Low Energy: Why Injectable NAD+ Is Getting So Much Attention Feeling foggy, drained, or burned out

L.et al (2022b)

The CYP1A2 gene has a well-studied polymorphism at position rs762551 that creates three distinct categories of caffeine metabolism: [2] The Three Metabolizer Types AA genotype (fast metabolizers): These individuals rapidly clear caffeine and typically experience its benefits without pronounced side effects

The glucagon receptor activation becomes measurably active at this level, which can cause a slight increase in heart rate (5-10 bpm) and a warmth sensation as thermogenesis increases